Results
| PMID | 24283984 |
| Gene Name | MUC16 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 59 |
| Population details | 59 (39 patients with histologically confirmed endometriosis, 20 patients without endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | EnolaseI, CA-125 |
| Other associated phenotypes |
Endometriosis |
|
Biomarkers. 2014 Feb;19(1):16-21. doi: 10.3109/1354750X.2013.863973. Epub 2013 Yun, Bo Hyon| Lee, You Sun| Chon, Seung Joo| Jung, Yeon Soo| Yim, Su Youn| Kim, Hye Yeon| Park, Joo Hyun| Seo, Seok Kyo| Cho, SiHyun| Choi, Young Sik| Lee, Byung Seok Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine , Seoul , Republic of Korea . OBJECTIVE: The aim of this study is to validate and investigate the clinical value of urinary enolase I in patients with endometriosis. METHODS: Urine samples of 39 patients with histologically confirmed endometriosis and 20 patients without endometriosis were collected. Western blot analysis and enzyme-linked immunosorbent assay were used to detect the increase of enolase I in patients' urine. RESULTS: Urinary enolase I expression corrected for creatinine ratio (non neuronal enolase (NNE)-Cr) was significantly greater in patients with endometriosis (p = 0.026). When the diagnostic performance of NNE-Cr was evaluated with serum CA-125 combination, the area under the curve was 0.821 (95% confidence interval 0.713-0.928) with sensitivity and specificity of 76.9% and 85.0%, respectively. CONCLUSION: Elevated urinary enolase I, in conjunction with serum CA-125, may be used as a potential biomarker for endometriosis. Mesh Terms: Adult| Biomarkers/urine| Biomarkers, Tumor/*urine| CA-125 Antigen/blood| Case-Control Studies| Creatinine/urine| DNA-Binding Proteins/*urine| Endometriosis/diagnosis/enzymology/*urine| Female| Humans| Phosphopyruvate Hydratase/*urine| ROC Curve |
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